P · 01
Safety
Patented closed-circuit cartridge keeps the operator out of the antineoplastic drug path. Collective protection at the source of risk — beyond PPE and CSTD alone.
Hospital pharmacy automation
Robotic compounding, plug & play.
ChemoMaker+® is the compact compounder for patient-specific oncology therapies — antineoplastic, biologic and immunotherapy drugs. It installs in your existing class II laminar flow hood, in a single day — no civil works, no dedicated room, no architectural redesign of your UFA. Clinically deployed across five Italian hospital pharmacies. Published evidence in SIFO 2023 · 2024 · 2025.
±1% Dosing accuracy
30 / h Throughput
30 kg Tabletop
1 day Install
Fig 01 · ChemoMaker+® Patented · CE marked · 2006/42/EC
0.41%
Avg error · Cremona
10.000+
Validated preparations
5
Hospital deployments
In clinical use — and in published SIFO evidence — at
A.O.U. G. Martino — Messina ◆ ASST Cremona ◆ ARNAS Civico — Palermo ◆ IRCCS CRO Aviano ◆ A.O.U. G. Martino — Messina ◆ ASST Cremona ◆ ARNAS Civico — Palermo ◆ IRCCS CRO Aviano ◆ A.O.U. G. Martino — Messina ◆ ASST Cremona ◆ ARNAS Civico — Palermo ◆ IRCCS CRO Aviano ◆
At a glance
Five operational facts.
Beyond the science — the five things a hospital pharmacy director cares about when evaluating whether ChemoMaker+® can actually be adopted next month.
- 01
Plug & play install
Inside the hood you already own.
Class II laminar flow hood, no civil works, no dedicated room. Installed in a single day.
- 02
Simple to use
Operator only at load and unload.
Touchscreen guidance under the hood. No specialised training, no new role to hire.
- 03
Maintenance-free
AI-assisted predictive maintenance.
The software warns you before a service is needed. No fixed schedule, no surprise downtime.
- 04
Hospital-integrated
Cato · Log80 · Deenova · HL7.
Certified integrations with the three software environments most used in EU hospital pharmacies. PDFs from any other system via the Universal Module.
- 05
Business continuity
48-hour fault replacement.
If the unit fails, a replacement is delivered within 48 hours. The pharmacy keeps running, the patient never waits.
What changes with ChemoMaker+®
Six engineering decisions that make automation finally fit your pharmacy.
P · 02
Accuracy
Real-time integrated gravimetric cell delivers an average dosing error of 1% — an order of magnitude tighter than the EU Pharmacopoeia tolerance.
P · 03
Traceability
Dual control via barcode and RFID on every vial and every container. Every step of the preparation is logged and signed by the ChemoPlan software.
P · 04
Staff freed up
The operator only intervenes at load and unload. While the robot doses, pharmacy technicians are free for other laboratory work.
P · 05
Residue management
Smart cartridges with embedded RFID are re-used for subsequent preparations until the very last second of drug stability — no manual tracking, no waste.
P · 06
Flexibility
Tabletop, 30 kg, fits inside the class II laminar flow hood you already own. Installed in a single day. No civil works.
For the Direttore Generale
A Collective Protection Device. Not just an upgrade of PPE.
Italian D.Lgs. 81/2008 — and every modern EU occupational safety framework — places preventive interventions at the source of the risk at the top of the hierarchy of controls, above PPE, CSTDs and hoods. By moving cytotoxic handling from the operator to a robotic closed-circuit path, ChemoMaker+® qualifies as a Collective Protection Device (DPC): the highest tier of operator protection available today for hospital pharmacy compounding. For hospital governance this is not a cosmetic improvement — when an enabling technology is reasonably available, the principle of "maximum reasonably practicable protection" makes its adoption a decision the General Direction can no longer defer.
- 01
Source-of-risk intervention
Removes the operator from the cytotoxic path rather than just shielding them from it.
- 02
Hierarchy of controls
Sits above CSTDs, hoods and PPE — the tier that EU and OSHA frameworks rank highest.
- 03
Managerial responsibility
Documented adoption of an available DPC strengthens the position of the Direttore Generale against liability risk.
“In presence of an enabling technology that is available, sustainable and aimed at reducing risk, the hospital is called to evaluate whether maintaining a predominantly manual process still represents the most adequate solution.”
— ChemoMaker+® Position Paper, §7 — Operator safety and exposure risk
Hierarchy of controls — EU/OSHA framework Tier
- 01
Elimination
Not applicable to patient-specific oncology therapies.
- 02
Substitution
Not applicable (molecules cannot be swapped).
- 03
Engineering controls
CPD · Collective Protection Device
ChemoMaker+® operates here — closed-circuit robotics, at the source of the risk.
- 04
Administrative controls
SOPs, procedures, operator training.
- 05
PPE
Gloves, gown, mask — the last line of defence.
The hierarchy of controls ranks interventions from most to least effective. Higher tiers are always preferable to lower ones.
Società Italiana
di Farmacia Ospedaliera
Congressi 2023 · 2024 · 2025
SIFO synthesis
Conclusions from hospital pharmacies that used ChemoMaker.
SIFO 2023
AOU G. Martino, Messina
Use of an automated system for the preparation of biological drugs at PIAC
“The implementation of an automated system within the Interdepartmental Centralized Outfitting Program allowed greater staff safety, sterility of the preparation, accuracy of formulation and traceability of the final product.”
SIFO 2024
SC Farmacia Aziendale, ASST Cremona
Introducing automation in the preparation of chemotherapy preparations
“ChemoMaker+® allows us to optimize resources, reduce time dedicated to preparation, lower risk for operators and improve patient care.”
SIFO 2025
ARNAS Civico Di Cristina Benfratelli, Palermo
Automation of oncological drug preparation in a UFA laboratory
“The involvement of personnel is required only in the loading/unloading phases — saving operator time, contributing to resource optimization, safety of operators and the quality of therapeutic services offered to patients.”
SIFO 2025
IRCCS CRO Aviano, Friuli-Venezia Giulia
Prospective evaluation of a robotic system for ancillary drug preparation at a UFA
“The complete automation of the dosing process, the reduced setup time and the versatility of the software settings confirm that the system is reliable, accurate and able to deliver repeatability and traceability for repetitive operations otherwise prone to error.”
Excerpted from independent abstracts published by the Italian Society of Hospital Pharmacy across the 2023, 2024 and 2025 National Congresses.
Read all clinical evidenceHow it fits your UFA
From hospital prescription to compounded dose, in one signed workflow.
- 01
Hospital software
Patient prescription enters ChemoPlan via HL7 — no custom integration required. Standalone operation also supported.
- 02
ChemoPlan — the bundled software
PC outside the hood. Manages the list of preparations to be made by ChemoMaker+®, reconciles partial vials, signs the record of every step. The pharmacist's command center.
- 03
ChemoMaker+® — the robot
Wireless dispatch to the robot inside the hood. The operator loads vials and containers. The robot doses, weighs, signs, labels.
Hospital integration
Already speaking your prescription system's language.
ChemoMaker+® ships with native HL7 connectors and tested integrations with the three software environments most commonly used in Italian and European hospital pharmacies. For everything else, our Universal Module ingests PDFs and screenshots from any prescription system and structures them into a signed job list — eliminating the manual re-typing that is the single most common source of compounding error.
Certified integrations
Cato ● Live
Hospital pharmacy ERP — ChemoMaker+® certified integration
Log80 ● Live
Antineoplastic prescription module — ChemoMaker+® certified integration
Deenova ● Live
Drug distribution & traceability — ChemoMaker+® certified integration
Universal Module
PDF & image ingestion. No IT project required.
For pharmacies running on non-integrated software (legacy or proprietary), our Universal Module reads PDFs, screenshots and printouts of the prescription and structures them automatically into a validated ChemoPlan job list. The pharmacist signs, the robot executes — zero manual re-typing, zero transcription errors.
- Prescription PDFs
- Screenshots / images
- Legacy / proprietary systems
- Pharmacist signs off-hood
Manual + CSTD · Legacy robotic isolator · ChemoMaker+®
ChemoMaker+® adapts to the pharmacy — instead of asking the pharmacy to adapt to the robot.
| Metric | Manual + CSTD | Legacy robotic isolator | ChemoMaker+® |
|---|---|---|---|
| Footprint | Hood-only | > 4 m³ · > 1,500 kg · dedicated room required | Tabletop · 30 kg · fits class II hood |
| Civil works | None | Architectural redesign of UFA required | None |
| Install time | N/A | Weeks (HVAC, qualification, fit-out) | Same day |
| Acquisition cost | Lowest upfront | Highest in market | 1/3 to 1/5 of legacy systems |
| Throughput | 15–20 doses/h, two pharmacy technicians required for cross-check | 15–20 doses/h, isolator-grade workflow | Up to 30 doses/h, operator needed only at load & unload |
| Dosing accuracy | ±10% (EU Pharmacopoeia) | ±5% | ±1% (real-time gravimetric) |
| Traceability | Paper / manual barcode | Barcode | Barcode + RFID dual control |
| Operator exposure | High — direct cytotoxic handling | Low | Effectively zero — closed cartridge path |
| Residue management | Spreadsheet, lossy | Not addressed | Automated via smart RFID cartridges |
| Hospital integration | Manual re-keying | Custom interface | HL7 standard, optional |
| Business continuity | Always available | Long downtime on fault | 48 h replacement unit guarantee |
Talk to the team
30 minutes with our clinical engineers.
We work closely with hospital pharmacy professionals across Europe. Tell us about your laminar flow hood, your prescription software and your annual volume — we'll build you a dedicated cost simulation against your own data, no obligation.